diff --git a/Zend/zend_API.c b/Zend/zend_API.c
index 1ace606a7e4..ad61ad66249 100644
--- a/Zend/zend_API.c
+++ b/Zend/zend_API.c
@@ -3230,12 +3230,18 @@ check_func:
 			}
 			return 0;
 		case IS_OBJECT:
-			if (Z_OBJ_HANDLER_P(callable, get_closure) && Z_OBJ_HANDLER_P(callable, get_closure)(Z_OBJ_P(callable), &fcc->calling_scope, &fcc->function_handler, &fcc->object) == SUCCESS) {
+			if (Z_OBJ_HANDLER_P(callable, get_closure)) {
+				if (Z_OBJ_HANDLER_P(callable, get_closure)(Z_OBJ_P(callable), &fcc->calling_scope, &fcc->function_handler, &fcc->object) == SUCCESS) {
 				fcc->called_scope = fcc->calling_scope;
 				if (fcc == &fcc_local) {
 					zend_release_fcall_info_cache(fcc);
 				}
 				return 1;
+				} else {
+					/* Discard exceptions thrown from Z_OBJ_HANDLER_P(callable, get_closure)
+					   TODO: extend get_closure() with additional argument and prevent exception throwing in the first place */
+					zend_clear_exception();
+			}
 			}
 			if (error) *error = estrdup("no array or string given");
 			return 0;
diff --git a/ext/ffi/tests/bug78543.phpt b/ext/ffi/tests/bug78543.phpt
new file mode 100644
index 00000000000..e2f014d7fc9
--- /dev/null
+++ b/ext/ffi/tests/bug78543.phpt
@@ -0,0 +1,12 @@
+--TEST--
+Bug #78543 (is_callable() on FFI\CData throws Exception)
+--SKIPIF--
+<?php require_once('skipif.inc'); ?>
+--FILE--
+<?php
+$ffi = FFI::cdef(' struct test { int dummy; }; ');
+$test = $ffi->new('struct test');
+var_dump(is_callable($test));
+?>
+--EXPECT--
+bool(false)