diff --git a/test/ruby/test_refinement.rb b/test/ruby/test_refinement.rb
index 6ce434790b..a6c5a438cf 100644
--- a/test/ruby/test_refinement.rb
+++ b/test/ruby/test_refinement.rb
@@ -2712,6 +2712,18 @@ class TestRefinement < Test::Unit::TestCase
     INPUT
   end
 
+  # [Bug #21265]
+  def test_symbol_proc_from_using_scope
+    assert_separately([], <<~RUBY)
+      class RefinedScope
+        using(Module.new { refine(Kernel) { def itself = 0 } })
+        ITSELF = :itself.to_proc
+      end
+
+      assert_equal(1, RefinedScope::ITSELF[1])
+    RUBY
+  end
+
   private
 
   def eval_using(mod, s)
diff --git a/vm_method.c b/vm_method.c
index c1793c102c..5d5d4884c0 100644
--- a/vm_method.c
+++ b/vm_method.c
@@ -1955,7 +1955,6 @@ resolve_refined_method(VALUE refinements, const rb_method_entry_t *me, VALUE *de
 
         tmp_me = me->def->body.refined.orig_me;
         if (tmp_me) {
-            if (defined_class_ptr) *defined_class_ptr = tmp_me->defined_class;
             return tmp_me;
         }